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2007
 Antiviral
Pathway Deregulation of Chronic Fatigue Syndrome Induces Nitric
Oxide Production in Immune Cells That Precludes a Resolution of
the Inflammatory Response. (Abstract) Journal of
Chronic Fatigue Syndrome Volume: 13 Issue: 4 2007 Marc Frémont
PhD, RED Laboratories, Brussels, B-1731, Belgium Freya Vaeyens MS,
RED Laboratories N.V., Brussels, B-1731, Belgium C. Vincent Herst
PhD, RED Laboratories N.V., Brussels, B-1731, Belgium Kenny De
Meirleir MD, PhD, Department of Human Physiology and Medicine,
Vrije Universiteit Brussel, Brussels, B-1051, Belgium Patrick
Englebienne PhD, Department of Nuclear Medicine, Free University
of Brussels, Brugmann Hospital, Brussels, B-1020, Belgium
"These results therefore suggest that chronic inflammation due to
excess nitric oxide production plays a role in CFS and that the
normal resolution of the inflammatory process by NF-kB activation
and apoptotic induction is impaired."
2006
Chronic
musculoskeletal pain in chronic fatigue syndrome: Recent
developments and therapeutic implications. (Abstract)
Nijs J, Meeus M, De Meirleir K. Department of Human Physiology,
Faculty of Physical Education and Physiotherapy, Vrije
Universiteit Brussel, Belgium; Department of Health Sciences,
Division of Musculoskeletal Physiotherapy, Higher Institute of
Physiotherapy, Hogeschool Antwerpen, Belgium. "CFS
sufferers respond to incremental exercise with a lengthened and
accentuated oxidative stress response, explaining muscle pain,
postexertional malaise, and the decrease in pain threshold
following graded exercise in CFS patients. Applying the scientific
evidence to the manual physiotherapy profession, pacing
self-management techniques and pain neurophysiology education are
indicated for the treatment of musculoskeletal pain in CFS
patients."
Lower
serum zinc in Chronic Fatigue Syndrome (CFS): relationships to
immune dysfunctions and relevance for the oxidative stress status
in CFS. (Abstract) Maes M, Mihaylova I, De Ruyter M.
M-Care4U Outpatient Clinics, Olmenlaan 9, 2610 Antwerp-Wilrijk,
Belgium. "There was a trend toward a significant negative
correlation between serum zinc and the severity of CFS and there
was a significant and negative correlation between serum zinc and
the subjective experience of infection. We found that serum zinc
was significantly and negatively correlated to the increase in the
alpha2 protein fraction and positively correlated to decreases in
the expression of mitogen-induced CD69+ (a T cell activation
marker) on CD3+ as well as CD3+CD8+ T cells. These results show
that CFS is accompanied by a low serum zinc status and that the
latter is related to signs of inflammation and defects in early T
cell activation pathways. Since zinc is a strong anti-oxidant, the
present results further support the findings that CFS is
accompanied by increased oxidative stress. The results of these
reports suggest that some patients with CFS should be treated with
specific antioxidants, including zinc supplements."
2005
Chronic
fatigue syndrome: assessment of increased oxidative stress and
altered muscle excitability in response to incremental exercise.
(Abstract) Jammes Y, Steinberg JG, Mambrini O, Bregeon F,
Delliaux S.; Laboratoire de Physiopathologie Respiratoire (UPRES
EA 2201), Faculte de Medecine, Institut Federatif de Recherche
Jean Roche, Marseille, France "The response of CFS
patients to incremental exercise associates a lengthened and
accentuated oxidative stress together with marked alterations of
the muscle membrane excitability. These two objective signs of
muscle dysfunction are sufficient to explain muscle pain and
postexertional malaise reported by our patients."
Exercise
capacity and immune function in male and female patients with
chronic fatigue syndrome (CFS). (Abstract) Snell
CR, Vanness JM, Strayer DR, Stevens SR. University of the Pacific,
Department of Sport Sciences, Stockton, CA 95211-0197, USA.
"These results implicate abnormal immune activity in the pathology
of exercise intolerance in CFS and are consistent with a
channelopathy involving oxidative stress and nitric oxide-related
toxicity."
Oxidative
stress levels are raised in chronic fatigue syndrome and are
associated with clinical symptoms. (Abstract)
Gwen Kennedy, Vance A Spence, Margaret McLaren, Alexander Hill,
Christine Underwood and Jill JF Belch Institution: Vascular
Diseases Research Unit, The Institute of Cardiovascular Research,
Ninewells Hospital and Medical School, Dundee, Scotland, UK
"This new data provides further evidence of dysfunction to
oxidative pathways in CFS. The finding of high levels of
isoprostanes in people with CFS is particularly important given
this measure’s sensitivity, reliability and correlation with other
measures of lipid peroxidation in vivo. Furthermore, isoprostanes
may not only be markers of oxidative injury, but may in fact
mediate the effects of free radicals and reactive oxygen species."
(Abstract
with comment)
2004
In
vivo magnetic resonance spectroscopy in chronic fatigue syndrome.
Chaudhuri A, Behan PO. Division of Clinical Neurosciences,
Institute of Neurological Sciences, Southern General Hospital,
University of Glasgow "Cell membrane oxidative stress may
offer a common explanation for the observed MRS changes in the
muscles and brain of CFS patients and this may have important
therapeutic implications."
2003
Relationship
between musculoskeletal symptoms and blood markers of oxidative
stress in patients with chronic fatigue syndrome.
(Abstract) Vecchiet J, Cipollone F, Falasca K, Mezzetti A,
Pizzigallo E, Bucciarelli T, De Laurentis S, Affaitati G, De
Cesare D, Giamberardino MA. Department of Medicine and Science of
Aging, G. D'Annunzio University of Chieti, Italy.
"Increased oxidative stress and decreased antioxidant defenses are
related to the extent of symptomatology in CFS, suggesting that
antioxidant supplementation might relieve muscle symptoms in the
syndrome."
Elevated
levels of protein carbonyls in sera of chronic fatigue syndrome
patients. Smirnova IV, Pall ML. Department of
Medicine, Division of Nephrology, New York Medical College,
Valhalla, NY, USA. "Protein carbonyl levels, a measure of
protein oxidation, were found to be significantly elevated (p <
0.0005) in the sera of chronic fatigue syndrome (CFS) patients vs.
controls. In contrast, the total protein levels in sera CFS
patients were unchanged from those of controls. The elevated
protein carbonyl levels confirm earlier reports suggesting that
oxidative stress is associated with chronic fatigue syndrome and
are consistent with a prediction of the elevated nitric oxide/peroxynitrite
theory of chronic fatigue syndrome and related conditions."
(Abstract
only)
2001
Elevated
nitric oxide/peroxynitrite mechanism for the common etiology of
multiple chemical sensitivity, chronic fatigue syndrome, and
posttraumatic stress disorder. Pall ML, Satterlee JD.
School of Molecular Biosciences, Washington State University,
Pullman 99164-4660, USA "Various types of evidence
implicate nitric oxide and an oxidant, possibly peroxynitrite, in
MCS and chemical intolerance (CI). The positive feedback loops
proposed earlier for CFS may explain the chronic nature of MCS
(CI) as well as several of its other reported properties. These
observations raise the possibility that this proposed elevated
nitric oxide/peroxynitrite mechanism may be the mechanism of a new
disease paradigm, answering the question raised by Miller earlier:
"Are we on the threshold of a new theory of disease?"
Antioxidant
status and lipoprotein peroxidation in chronic fatigue syndrome.
(Abstract) Manuel y Keenoy B, Moorkens G, Vertommen J, De
Leeuw I. University Hospital, University of Antwerp, Belgium.
"These results indicate that patients with CFS have increased
susceptibility of LDL and VLDL to copper-induced peroxidation and
that this is related both to their lower levels of serum
transferrin and to other unidentified pro-oxidising effects of CFS."
2000
Blood
parameters indicative of oxidative stress are associated with
symptom expression in chronic fatigue syndrome.
(Abstract) Richards RS, Roberts TK, McGregor NR, Dunstan RH, Butt
HL. Department of Biological Sciences, University of Newcastle,
Australia. "These data suggest that oxidative stress due
to excess free radical formation is a contributor to the pathology
of CFS and was associated with symptom presentation."
Specific
oxidative alterations in vastus lateralis muscle of patients with
the diagnosis of chronic fatigue syndrome. (Abstract)
Fulle S, Mecocci P, Fano G, Vecchiet I, Vecchini A, Racciotti D,
Cherubini A, Pizzigallo E, Vecchiet L, Senin U, Beal MF. Lab.
Interuniversitario di Miologia, Dip. Biologia Cellulare e
Molecolare, Universita di Perugia, Perugia, Italy "From
these results we hypothesize that in CFS there is oxidative stress
in muscle, which results in an increase in antioxidant defenses.
Furthermore, in muscle membranes, fluidity and fatty acid
composition are significantly different in specimens from CFS
patients as compared to controls and to patients suffering from
fibromyalgia. These data support an organic origin of CFS, in
which muscle suffers oxidative damage."
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