cerebrospinal fluid proteomes differentiate post-treatment lyme
disease from chronic fatigue syndrome.
Schutzer SE, Angel TE, Liu T, Schepmoes AA, Clauss TR, Adkins
JN, Camp DG, Holland BK, Bergquist J, Coyle PK, Smith RD, Fallon
BA, Natelson BH. Department of Medicine, University of Medicine
and Dentistry of New Jersey-New Jersey Medical School, Newark,
New Jersey, United States of America. "Example of proteins in
common and elevated in abundance in the two disease conditions,
compared to normal, but at different levels."
cardiovascular control during orthostatic stress and isometric
exercise in adolescent chronic fatigue syndrome.
Wyller VB, Saul JP, Walloe L, Thaulow E "...our
results suggest that CFS patients suffer from a more comprehensive
disturbance of sympathetic cardiovascular regulation than
previously acknowledged, supporting the hypothesis that
dysautonomia may be a central etiologic component of CFS (Freeman
and Komaroff 1997). Specifically, the sympathetic nervous
system is more activated at rest, and seems to have an enhanced
response to orthostatic stress, but has a reduced response to the
addition of isometric exercise. These abnormalities may
account for the high prevalence of orthostatic symptoms among CFS
Thermoregulatory Responses in Adolescents With Chronic Fatigue
Syndrome: Relation to Clinical Symptoms
Vegard Bruun Wyller, MDa,b, Kristin Godang, BScc, Lars Mørkrid,
MD, PhDd, Jerome Philip Saul, MDe, Erik Thaulow, MD, PhDa and Lars
Walløe, MD, PhDb; Departments of Pediatrics, Endocrinology,
Medical Biochemistry, Rikshospitalet-Radiumhospitalet Medical
Center, Oslo, Norway; Department of Physiology, University of
Oslo, Oslo, Norway; Department of Pediatrics, Medical University
of South Carolina, Charleston, South Carolina "Taken together,
our results suggest that adolescent patients with CFS have
abnormal catecholaminergic-dependent thermoregulatory responses
both at rest and during local skin cooling. These results seem to
support a hypothesis of sympathetic dysfunction in CFS.5,6
Furthermore, they might explain important clinical symptoms."
Twin Study of Cognitive Function in Chronic Fatigue Syndrome: The
Effects of Sudden Illness Onset.
Claypoole, Keith H.; Noonan,
Carolyn; Mahurin, Roderick K.; Goldberg, Jack; Erickson, Tom;
Buchwald, Dedra; Department of Psychology, University of Hawaii,
Honolulu, HI, US; University of Washington School of Medicine,
Seattle, WA, US "CFS is associated with
neuropsychological deficits across multiple cognitive domains, and
in some domains - notably speed of information processing -
individuals with a sudden onset of illness may be more impaired
than those with a gradual onset. The reasons behind this are
unclear, but they may reflect an infectious trigger and
involvement of the central nervous system. In addition, our
findings may have clinical implications for determining disability
among individuals with CFS...."
with chronic fatigue syndrome have reduced absolute cortical blood
(Abstract) Yoshiuchi K, Farkas J, Natelson BH. Department of
Neurosciences, Fatigue Research Center, UMDNJ-New Jersey Medical
School, Newark, USA "These data indicate that patients
with CFS have reduced absolute cortical blood flow in rather broad
areas when compared with data from healthy controls and that those
devoid of psychopathology had the most reductions in cortical
flow. These data support, in part, our earlier findings that
patients devoid of psychopathology are the group most at risk of
having some of the symptoms of CFS due to brain dysfunction."
responsiveness is an essential feature of chronic fatigue
syndrome: A fMRI study.
Masaaki Tanaka,1 Norihiro Sadato,2,3 Tomohisa Okada,2 Kei
Mizuno,1 Tetsuya Sasabe,1,4 Hiroki C Tanabe,2 Daisuke N Saito,2
Hirotaka Onoe,5 Hirohiko Kuratsune,6 and Yasuyoshi Watanabe1,3
1Department of Physiology, Osaka City University Graduate School
of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
2Division of Cerebral Integration, Department of Cerebral
Research, National Institute for Physiological Sciences, 38
Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan 3Japan
Science and Technology Corporation (JST)/Research Institute of
Science and Technology for Society (RISTEX), 4-1-8 Honcho,
Kawaguchi, Saitama 332-0012, Japan 4Department of Oral Physiology,
Osaka University Graduate School of Dentistry, 1-8 Yamadaoka,
Suita, Osaka 565-0871, Japan 5Department of Psychology, Tokyo
Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu,
Tokyo 183-8526, Japan 6Department of Health Science, Faculty of
Health Science for Welfare, Kansai University of Welfare Sciences,
3-11-1 Asahigaoka, Kashihara, Osaka 582-0026, Japan "...we
believe that this new method could facilitate the diagnosis of CFS.
In addition, since attenuation rate was positively correlated with
pre-experiment VAS scores in the CFS patients (R2 = 0.828, P =
0.012), we propose this parameter as a new objective and
quantitative scale to measure the severity of CFS."
fluid abnormalities in patients with chronic fatigue syndrome.
Natelson BH, Weaver SA, Tseng CL, Ottenweller JE. CFS
Cooperative Research Center and Department of Neurosciences,
University of Medicine and Dentistry of New Jersey-New Jersey
Medical School, Newark, New Jersey, USA "The results support
two hypotheses: that some CFS patients have a neurological
abnormality that may contribute to the clinical picture of the
illness and that immune dysregulation within the central nervous
system may be involved in this process."
matter volume reduction in the chronic fatigue syndrome.
de Lange FP, Kalkman JS, Bleijenberg G, Hagoort P, van
der Meer JW, Toni I.
F.C. Donders Centre for Cognitive Neuroimaging, Radboud University
Nijmegen, NL-6500 HB Nijmegen, The Netherlands. "These findings
suggest that the central nervous system plays a key role in the
pathophysiology of CFS and point to a new objective and
quantitative tool for clinical diagnosis of this disabling
evidence of cognitive complaints in Chronic Fatigue Syndrome: a
BOLD fMRI study of verbal working memory.
Lange G, Steffener J, Cook DB, Bly BM, Christodoulou C, Liu
WC, Deluca J, Natelson BH. Department of Radiology, University of
Medicine and Dentistry of New Jersey-New Jersey Medical School,
Newark, 07103, USA "Our findings provide objective evidence for
the subjective experience of cognitive difficulties in individuals
underlying fatigue: a voxel-based morphometric study of chronic
fatigue syndrome. Okada T, Tanaka M, Kuratsune H,
Watanabe Y, Sadato N "We found that patients with chronic
fatigue syndrome had reduced gray-matter volume in the bilateral
prefrontal cortex. Within these areas, the volume reduction in the
right prefrontal cortex paralleled the severity of the fatigue of
fatigue syndrome: new evidence for a central fatigue disorder.
Georgiades E, Behan WM, Kilduff LP, Hadjicharalambous M,
Mackie EE, Wilson J,
Ward SA, Pitsiladis YP. Centre for Exercise Science and
Medicine, Institute of Biomedical & Life Sciences,
University of Glasgow, Glasgow G12 8QQ, Scotland, UK.
"Peak oxygen uptake was significantly lower in the CFS patients
compared with controls. The significant differences observed in a
number of key putative CNS 5-HT and dopaminergic modulators,
coupled with the exacerbated perception of effort, provide further
evidence for a potentially significant role for CNS mechanisms in
the pathogenesis of CFS."
in the Cerebrospinal Fluid of the Following Infectious Agents in a
Cohort of 12 CFS Subjects: Human Herpes Virus-6 and 8; Chlamydia
Species; Mycoplasma Species; EBV; CMV; and Coxsackievirus
(Abstract) Susan Levine, MD; affiliated with the New
Jersey Chronic Fatigue Syndrome Association. "...we
sought to determine the prevalence of HHV-6, HHV-8, Epstein-Barr
Virus (EBV), cytomegalovirus (CMV), Mycoplasma species, Chlamydia
species, and Coxsackie virus in the spinal fluid of a group of 12
patients with CFS. Although we intended to search mainly for
evidence of actively replicating HHV-6, a virus that has been
associated by several researchers with this disorder, we found
evidence of HHV-8, Chlamydia species, CMV and Coxsackie virus in
roles of orthostatic hypotension, orthostatic tachycardia, and
subnormal erythrocyte volume in the pathogenesis of the chronic
(Abstract)Streeten DH, Thomas
D, Bell DS. Department of Medicine, State University of New
York Health Science Center, Syracuse 13210, USA. "Delayed
orthostatic hypotension and/or tachycardia caused by excessive
gravitational venous pooling, which is correctable with external
lower-body compression, together with subnormal circulating
erythrocyte volume, are very frequent, although not invariably
demonstrable, findings in moderate to severe chronic fatigue
syndrome. When present, they may be involved in its pathogenesis."
Intolerance in Adolescent Chronic Fatigue Syndrome.
(Abstract) Julian M. Stewart*, Michael H. Gewitz*, Amy Weldon*,
Nina Arlievsky, Karl Li, and Jose Munoz From the Department of
Pediatrics, * Divisions of Cardiology, and Immunology and
Infectious Disease, New York Medical College, Valhalla, New York.
"We conclude that chronic fatigue syndrome is highly related to
orthostatic intolerance in adolescents. The orthostatic
intolerance of CFS often has heart rate and BP responses similar
to responses in the syndrome of orthostatic tachycardia suggesting
that a partial autonomic defect may contribute to symptomatology
in these patients."
motor potential alterations in chronic fatigue syndrome.
(Abstract) Gordon R, Michalewski HJ, Nguyen T, Gupta S,
Starr A. Department of Neurology, University of California,
Irvine, Med. Surge I, Room 154, Irvine, CA 92697-4290, USA.
"The findings in CFS of slowed RTs and reduced premovement-related
potentials suggest that central motor mechanisms accompanying
motor response preparation were impaired in CFS for some tasks."
of exhaustive treadmill exercise on cognitive functioning in
chronic fatigue syndrome. (Abstract) LaManca JJ, Sisto
SA, DeLuca J, Johnson SK, Lange G, Pareja J, Cook S, Natelson BH.
Chronic Fatigue Syndrome Cooperative Research Center, University
of Medicine and Dentistry of New Jersey-New Jersey Medical School,
Newark, USA. "We conclude that after physically demanding
exercise, CFS subjects demonstrated impaired cognitive processing
compared with healthy individuals."
associative learning in chronic fatigue syndrome.
(Abstract) Servatius RJ, Tapp WN, Bergen MT, Pollet CA, Drastal
SD, Tiersky LA, Desai P, Natelson BH. New Jersey Medical School,
Department of Neuroscience, East Orange 07019, USA "These
data suggest organic brain dysfunction within a defined neural
substrate in CFS patients."
of chronic fatigue syndrome: a critical review.
(Abstract) Tiersky LA, Johnson SK, Lange G, Natelson BH, DeLuca J.
Department of Physical Medicine and Rehabilitation, UMDNJ-New
Jersey Medical School, Kessler Institute for Rehabilitation, West
Orange 07052, USA. "Although the neuropathological
processes underlying cognitive dysfunction in CFS are not yet
known, preliminary evidence suggests the involvement of cerebral
white matter. Directions for future research are outlined."
fatigue syndrome--aetiological aspects. (Abstract)
Dickinson CJ. Wolfson Institute of Preventive Medicine, St.
Bartholomew's & Royal London School of Medicine & Dentistry,
London, UK. "...many magnetic resonance imaging (MRI)
studies already suggest that small discrete patchy brain stem and
subcortical lesions can often be seen in CFS. Regional blood flow
studies by single photon-emission computerized tomography (SPECT)
have been more consistent. They have revealed blood flow
reductions in many regions, especially in the hind brain. Similar
lesions have been reported after poliomyelitis and in multiple
sclerosis--in both of which conditions chronic fatigue is
findings in children with chronic fatigue syndrome. (abstract)Goldberg
MD, Mena I, Darcourt J NeuroSPECT studies have described
specific abnormalities in cerebral perfusion in adults with
criteria for Chronic Fatigue Syndrome. This reports findings in 13
children with criteria for Chronic Fatigue Syndrome. NeuroSPECT is
presented as a quantifiable, reproducible tool that can allow us
to document a cohort of children defined as CFS/CFIDS."
vagal power during treadmill walking in patients with chronic
fatigue syndrome. (Abstract) Cordero DL, Sisto SA, Tapp
WN, LaManca JJ, Pareja JG, Natelson BH. Fatigue Research Center,
DVA Medical Center, East Orange, NJ 07018, USA.
"...patients had a significant decline in resting vagal power
after periods of walking. These results suggest a subtle
abnormality in vagal activity to the heart in patients with the
chronic fatigue syndrome and may explain, in part, their post-exertional
impairment of auditory processing in chronic fatigue syndrome: a
comparison with multiple sclerosis and healthy controls.
(Abstract) Johnson SK, DeLuca J, Diamond BJ, Natelson BH.
Chronic Fatigue Syndrome Research Center, Research Department,
Kessler Institute for Rehabilitation, West Orange, NJ 07052, USA.
"The group with Chronic Fatigue Syndrome was differentially
impaired on the auditory relative to the visual processing task.
The group with Multiple Sclerosis was equally impaired on both
versions of the task. The results are discussed within the
framework of Baddeley's model of working memory."
perfusion is impaired in chronic fatigue syndrome.
(Abstract) Costa DC, Tannock C, Brostoff J. Department of
Psychiatry, UCL Medical School, London, UK. "Patients
with ME/CFS have a generalized reduction of brain perfusion, with
a particular pattern of hypoperfusion of the brainstem."
imaging of the brain: comparison of findings in patients with
chronic fatigue syndrome, AIDS dementia complex, and major
unipolar depression. (Abstract) Schwartz RB, Komaroff
AL, Garada BM, Gleit M, Doolittle TH, Bates DW, Vasile RG, Holman
BL. Department of Radiology, Brigham and Women's Hospital, Boston,
MA 02215. "These findings are consistent with the
hypothesis that chronic fatigue syndrome may be due to a chronic
of intracranial abnormalities in patients with chronic fatigue
syndrome: comparison of MR imaging and SPECT.
(Abstract) Schwartz RB, Garada
BM, Komaroff AL, Tice HM, Gleit M, Jolesz FA, Holman BL.
Department of Radiology, Brigham and Women's Hospital, Boston, MA
02115. "SPECT abnormalities occur more frequently and in
greater numbers than MR abnormalities do in patients with chronic
fatigue syndrome. SPECT may prove to be useful in following the
clinical progress of patients with this syndrome."
processing efficiency in chronic fatigue syndrome and multiple
sclerosis. (Abstract) DeLuca J, Johnson SK, Natelson BH.
Department of Physical Medicine and Rehabilitation, University of
Medicine and Dentistry of New Jersey-New Jersey Medical School,
Newark. "These results indicate that subjects with CSF
and subjects with MS show significant impairment on a test of
complex concentration when compared with appropriate controls. The
data suggest that subjects with CFS and subjects with MS have
difficulty on tasks that require the simultaneous processing of
complex cognitive information."
of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic
fatigue syndrome. (Abstract) Ichise M, Salit IE,
Abbey SE, Chung DG, Gray B, Kirsh JC, Freedman M. Department of
Radiology (Division of Nuclear Medicine), University of Toronto,
Canada. "99Tcm-HMPAO brain SPECT provided objective
evidence for functional impairment of the brain in the majority of
the CFS subjects."