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2007
 Post-exertional
Symptomology In Chronic Fatigue Syndrome
(Abstract)
Stiles, Travis L.; Snell, Christopher R.; Stevens, Staci R.;
Moran, Megan; VanNess, J. Mark (CFS Medicine & Science in Sports &
Exercise: Volume 39(5) Supplement, May 2007 "The results
of this study indicate that CFS patients suffer symptom
exacerbation following physical stress. As with MS, lupus and RA,
post-exertional symptom exacerbation appears to be both a real and
incapacitating feature of the syndrome. The delayed recovery
response evoked by a single bout of exercise stress is distinctly
different from that of sedentary controls."
2005
Exercise
capacity and immune function in male and female patients with
chronic fatigue syndrome (CFS). (Abstract) Snell
CR, Vanness JM, Strayer DR, Stevens SR. University of the Pacific,
Department of Sport Sciences, Stockton, CA 95211-0197, USA.
"These results implicate abnormal immune activity in the pathology
of exercise intolerance in CFS and are consistent with a
channelopathy involving oxidative stress and nitric oxide-related
toxicity."
Chronic
fatigue syndrome: assessment of increased oxidative stress and
altered muscle excitability in response to incremental exercise.
(Abstract) Jammes Y, Steinberg JG, Mambrini O, Bregeon F,
Delliaux S. Laboratoire de Physiopathologie Respiratoire (UPRES EA
2201), Faculte de Medecine, Institut Federatif de Recherche Jean
Roche, Marseille, France. "The response of CFS patients
to incremental exercise associates a lengthened and accentuated
oxidative stress together with marked alterations of the muscle
membrane excitability. These two objective signs of muscle
dysfunction are sufficient to explain muscle pain and
postexertional malaise reported by our patients."
2002
Brain
regions involved in fatigue sensation: reduced acetylcarnitine
uptake into the brain.
(Abstract) Kuratsune H,
Yamaguti K, Lindh G, Evengard B, Hagberg G, Matsumura K, Iwase M,
Onoe H, Takahashi M, Machii T, Kanakura Y, Kitani T, Langstrom B,
Watanabe Y. Department of Molecular Medicine, Hematology and
Oncology, Osaka University Graduate School of Medicine, C9, 2-2
Yamada-oka, Suita, Osaka 565-0871, Japan. "These findings
suggest that the levels of biosynthesis of neurotransmitters
through acetylcarnitine might be reduced in some brain regions of
chronic fatigue patients and that this abnormality might be one of
the keys to unveiling the mechanisms of the chronic fatigue
sensation."
1999
Demonstration
of delayed recovery from fatiguing exercise in chronic fatigue
syndrome. (Abstract) Paul L, Wood L, Behan WM, Maclaren
WM. (1999) Department of Physiotherapy, Glasgow Caledonian
University, Glasgow, Scotland. "These findings support
the clinical complaint of delayed recovery after exercise in
patients with CFS."
Impaired
oxygen delivery to muscle in chronic fatigue syndrome. (Abstract)
McCully KK, Natelson BH. Department of Medicine, Medical College
of Pennsylvania and Hahnemann University, Philadelphia, PA 19129
"In conclusion, oxygen delivery was reduced in CFS patients
compared with that in sedentary controls. This result is
consistent with previous studies showing abnormal autonomic
control of blood flow."
In
vitro Study of Muscle Aerobic Metabolism in Chronic Fatigue
Syndrome (Abastract)
Wilhelmina M.H. Behan, Senior Lecturer, Pathology, Glasgow
University, Glasgow, Scotland, U.K.; Ian J. Holt, Royal Society
University Research Fellow, Department of Biochemical Medicine,
Ninewells Medical School, Dundee, Scotland, U.K.; David H. Kay,
House Officer, Western Infirmary, Glasgow, Scotland, U.K. Pamela
Moonie, Research Assistant, Department of Biochemical Medicine,
Ninewells Medical School , Dundee, Scotland, U.K. "This in vitro
study confirms that there is convincing evidence of mild aerobic
defects in skeletal muscle in some cases of CFS."
(Full
Article)
1998
Influence
of exhaustive treadmill exercise on cognitive functioning in
chronic fatigue syndrome. (Abstract)
LaManca JJ, Sisto SA, DeLuca J, Johnson SK, Lange G, Pareja J,
Cook S, Natelson BH. Chronic Fatigue Syndrome Cooperative
Research Center, University of Medicine and Dentistry of New
Jersey-New Jersey Medical School, Newark, USA. "We conclude
that after physically demanding exercise, CFS subjects
demonstrated impaired cognitive processing compared with healthy
individuals."
1996
Reduced
oxidative muscle metabolism in chronic fatigue syndrome.
(Abstract) McCully KK, Natelson BH, Iotti S, Sisto S, Leigh JS
Jr. Department of Medicine, Medical College of Pennsylvania,
Philadelphia 19131, USA. "In conclusion, oxidative
metabolism is reduced in CFS patients compared to sedentary
controls."
1995
Unusual pattern of mitochondrial DNA
deletions in skeletal muscle of an adult human with chronic
fatigue syndrome. Zhang C, Baumer A, Mackay IR, Linnane
AW, Nagley P. Human Molecular Genetics 1995; 4(4): 751-4.
(Abstract not available)
1994
Acetylcarnitine
deficiency in chronic fatigue syndrome. (Abstract)
Kuratsune H, Yamaguti K, Takahashi M, Misaki H, Tagawa S, Kitani
T. Osaka University Medical School, Japan. "...the
concentration of serum acylcarnitine in patients with CFS tended
to increase to the normal level with the recovery of general
fatigue. Therefore, the measurement of acylcarnitine would be a
useful tool for the diagnosis and assessment of the degree of
clinical manifestation in patients with CFS."
1992
Skeletal
muscle metabolism in the chronic fatigue syndrome. In vivo
assessment by 31P nuclear magnetic resonance spectroscopy.
(Abstract) Wong R, Lopaschuk G, Zhu G, Walker D, Catellier D,
Burton D, Teo K, Collins-Nakai R, Montague T. Department of
Medicine, University of Alberta, Edmonton, Canada.
"Patients with CFS and normal control subjects have similar
skeletal muscle metabolic patterns during dynamic exercise and
reach similar clinical and metabolic end points. However, CFS
patients reach exhaustion much more rapidly than normal subjects,
at which point they also have relatively reduced intracellular
concentrations of ATP. These data suggest a defect of oxidative
metabolism with a resultant acceleration of glycolysis in the
working skeletal muscles of CFS patients. This metabolic defect
may contribute to the reduced physical endurance of CFS patients.
Its etiology is unknown. Whether CFS patients' overwhelming
tiredness at rest has a similar metabolic pathophysiology or
etiology also remains unknown."
1991
Mitochondrial
abnormalities in the postviral fatigue syndrome.
(Abstract) Behan WM, More IA, Behan PO. Department of
Pathology, University of Glasgow, Scotland. "We have
examined the muscle biopsies of 50 patients who had postviral
fatigue syndrome (PFS) for from 1 to 17 years. We found mild to
severe atrophy of type II fibres in 39 biopsies, with a mild to
moderate excess of lipid. On ultrastructural examination, 35 of
these specimens showed branching and fusion of mitochondrial
cristae. Mitochondrial degeneration was obvious in 40 of the
biopsies with swelling, vacuolation, myelin figures and secondary
lysosomes. These abnormalities were in obvious contrast to control
biopsies, where even mild changes were rarely detected. The
findings described here provide the first evidence that PFS may be
due to a mitochondrial disorder precipitated by a virus
infection."
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