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2007
 Diminished
Cardiopulmonary Capacity During Post-Exertional Malaise
(Abstract) J. Mark VanNess PhD, Christopher R. Snell PhD,
Staci R. Stevens "Conclusion: In the absence of a second
exercise test, the lack of any significant differences for the
first test would appear to suggest no functional impairment in CFS
patients. However, the results from the second test indicate the
presence of a CFS related post-exertional malaise. It might be
concluded then that a single exercise test is insufficient to
demonstrate functional impairment in CFS patients. A second test
may be necessary to document the atypical recovery response and
protracted malaise unique to CFS. (See related full text
article
Legal
and Scientific Considerations of the Exercise Stress Test
Ciccolla, Stevens, Snell, Van Ness, ©2007 The Haworth Press
"This article examines the legal and scientific basis on which an
exercise stress test can provide medically acceptable evidence of
disability for the CFS patient.")
Sympathetic
cardiovascular control during orthostatic stress and isometric
exercise in adolescent chronic fatigue syndrome.
Wyller VB, Saul JP, Walloe L, Thaulow E "...our results
suggest that CFS patients suffer from a more comprehensive
disturbance of sympathetic cardiovascular regulation than
previously acknowledged, supporting the hypothesis that
dysautonomia may be a central etiologic component of CFS (Freeman
and Komaroff 1997). Specifically, the sympathetic nervous
system is more activated at rest, and seems to have an enhanced
response to orthostatic stress, but has a reduced response to the
addition of isometric exercise. These abnormalities may
account for the high prevalence of orthostatic symptoms among CFS
patients.
2006
Patients
with chronic fatigue syndrome have reduced absolute cortical blood
flow. (Abstract) Yoshiuchi K, Farkas J, Natelson
BH. Department of Neurosciences, Fatigue Research Center,
UMDNJ-New Jersey Medical School, Newark, USA. "These data
indicate that patients with CFS have reduced absolute cortical
blood flow in rather broad areas when compared with data from
healthy controls...."
Plasma
endothelin-1 levels in chronic fatigue syndrome.
(Abstract) Publication: Kennedy G, Spence V, Khan F, Belch JJF.
Institution: Dr Gwen Kennedy et al, Department of Medicine,
University of Dundee. "...these experimental data challenge the
concept that CFS and FMS are part of the same spectrum of illness.
Normal ET-1 levels in CFS patients in conjunction with a
previously-reported enhanced endothelial response to acetylcholine
may predispose these patients to abnormal cardiovascular responses
to orthostatic challenge."
2004
Prevalence
of abnormal cardiac wall motion in the cardiomyopathy associated
with incomplete multiplication of Epstein-barr Virus and/or
cytomegalovirus in patients
with chronic fatigue syndrome. (Abstract) Lerner AM,
Dworkin HJ, Sayyed T, Chang CH, Fitzgerald JT, Beqaj S, Deeter RG,
Goldstein J, Gottipolu P, O'Neill W. Department of Medicine,
William Beaumont Hospital, Royal Oak, Michigan, USA. "A progressive cardiomyopathy caused by incomplete virus
multiplication of EBV and/or HCMV in CFS patients is present."
Acetylcholine
mediated vasodilatation in the microcirculation of patients with
chronic fatigue syndrome. (Full Article) V.A.
Spence, F. Khan*, G. Kennedy, N.C. Abbot, J.J.F. Belch; Vascular
Diseases Research Unit, University Department of Medicine,
Ninewells Hospital & Medical School, Dundee DD1 9SY, UK
"Most diseases are accompanied by a blunted response to
acetylcholine but the opposite is true for CFS. Such sensitivity
is normally associated with physical training so the finding in
CFS is anomalous and may well be relevant to vascular symptoms
that characterise many patients."
Peripheral
cholinergic function in humans with chronic fatigue syndrome, Gulf
War syndrome and with illness following organophosphate exposure.
(Full Article) Authors: Khan F, Kennedy G, Spence VA, Newton DJ
and Belch JJF; Institution: Vascular Diseases Research Unit, The
Institute of Cardiovascular Research, University of Dundee.
"Although there are many clinical similarities between these three
illnesses, our results indicate peripheral cholinergic
abnormalities in the vascular endothelium of only patients with CFS, suggesting that this syndrome has a different aetiology,
which might involve inhibition of vascular cholinesterase."
(Abstract
only)
2003
Abnormal
impedance cardiography predicts symptom severity in chronic
fatigue syndrome. (Full Article) Peckerman A, LaManca
JJ, Dahl KA, Chemitiganti R, Qureishi B, Natelson BH.Department of
Neurosciences, CFS Cooperative Research Center, University of
Medicine and Dentistry of New Jersey, Newark, NJ, USA.
"These results provide a preliminary indication of reduced
circulation in patients with severe CFS."
(Abstract
only)
Prolonged
acetylcholine-induced vasodilatation in the peripheral
microcirculation of patients with chronic fatigue syndrome.
(Full Article)
Faisel Khan, Vance Spence, Gwen Kennedy and Jill J. F. Belch
Vascular Diseases Research Unit, University Department of
Medicine, Ninewells Hospital and Medical School, Dundee, UK.
"Prolongation of ACh-induced vasodilatation is suggestive of a
disturbance to cholinergic pathways, perhaps within the vascular
endothelium of patients with CFS, and might be related to some of
the unusual vascular symptoms, such as hypotension and orthostatic
intolerance, which are characteristic of the condition."
(Abstract
only)
Assessment
of cardiovascular reactivity by fractal and recurrence
quantification analysis of heart rate and pulse transit time.
JE Naschitz, R Itzhak, N Shaviv, I Khorshidi, S Sundick, H
Isseroff, M Fields, RM Priselac, D Yeshurun and E Sabo, Department
of Internal Medicine A, Bnai-Zion Medical Center and Bruce
Rappaport Faculty of Medicine, Technion-Israel Institute of
Technology, Haifa, Israel; Rheumatology, Bnai-Zion Medical Center
and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute
of Technology, Haifa, Israel "...13 variables showed
significant differences between CFS and controls."
2002
Hemodynamics
instability score in chronic fatigue syndrome and in non-chronic
fatigue syndrome. (Abstract) Naschitz JE, Sabo E,
Naschitz S, Rosner I, Rozenbaum M, Fields M, Isseroff H, Priselac
RM, Gaitini L, Eldar S, Zukerman E, Yeshurun D. Departments of
Internal Medicine A, Rheumatology, Anesthesiology, and Surgery,
Bnai Zion Medical Center and Bruce Rappaport Faculty of Medicine,
Technion-Israel Institute of Technology, Haifa, Israel.
"The cardiovascular reactivity in patients with CFS has certain
features in common with the reactivity in patients with recurrent
syncope or non-CFS chronic fatigue, such as the frequent
occurrence of vasodepressor reaction, cardioinhibitory reaction,
and postural tachycardia syndrome. Apart from to these shared
responses, the large majority of CFS patients exhibit a particular
abnormality..."
2000
The
roles of orthostatic hypotension, orthostatic tachycardia, and
subnormal erythrocyte volume in the pathogenesis of the chronic
fatigue syndrome. (Abstract) Streeten DH, Thomas
D, Bell DS. Department of Medicine, State University of New
York Health Science Center, Syracuse 13210, USA. "Delayed
orthostatic hypotension and/or tachycardia caused by excessive
gravitational venous pooling, which is correctable with external
lower-body compression, together with subnormal circulating
erythrocyte volume, are very frequent, although not invariably
demonstrable, findings in moderate to severe chronic fatigue
syndrome. When present, they may be involved in its pathogenesis."
1999
Orthostatic
Intolerance in Adolescent Chronic Fatigue Syndrome.
(Abstract) Julian M. Stewart*, Michael H. Gewitz*, Amy Weldon*,
Nina Arlievsky, Karl Li, and Jose Munoz From the Department of
Pediatrics, * Divisions of Cardiology, and Immunology and
Infectious Disease, New York Medical College, Valhalla, New York.
"We conclude that chronic fatigue syndrome is highly related to
orthostatic intolerance in adolescents. The orthostatic
intolerance of CFS often has heart rate and BP responses similar
to responses in the syndrome of orthostatic tachycardia suggesting
that a partial autonomic defect may contribute to symptomatology
in these patients."
1998
Circulating
Blood Volume in Chronic Fatigue Syndrome. (Full
Article)
David H. P. Streeten, MB, DPhil, FRCP, FACP; David S. Bell, MD,
FAAP "The high prevalence and frequent severity of the low RBC mass suggest that this abnormality might contribute to the
symptoms of CFS by reducing the oxygen-carrying power of the blood
reaching the brain in many of these patients."
1997
Myagic
Encephalomyelitis (ME): A Haemorheological Disorder
Manifested as Impaired Capillary blood Flow. Leslie
O. Simpson, Ph.D., Journal of Orthomolecular Medicine Vol. 12, No.
2, 1997. "The consequences of stiffened, shape-changed
red cells would be to impair capillary blood flow particularly in
tissues with smaller than usual mean capillary diameters.
The degree of reduction in the rates of delivery of oxygen and
nutrient substrates would be related to symptom severity."
Cardiac
Involvement in Patients with Chronic Fatigue Syndrome as
Documented with Holter and Biopsy Data in Birmingham, Michigan,
1991-1993 (Abstract) A. Martin Lerner, James
Goldstein, Chug-ho Chang, Marcus Zervos, James T. Fitzgerald,
Howard J. Dworkin, Claudine Lawrie-Hoppen, Steven M. Korotkin,
Marc Brodsky, and William O'Neil. "Right ventricular
endomyocardial biopsies in CFS patients showed a single patient
with lymphocytic myocarditis. Light and electron microscopic
cardiomyopathic changes were present in the others."
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